Thesis
Investigating brain-derived α-synuclein fibrils and diagnostic biomarkers of synucleinopathies
- Abstract:
-
Synucleinopathies are associated with the aggregation of misfolded alpha-synuclein (αSyn) into fibrils. These αSyn fibrils are categorised into different ’strains’ according to their biological properties. In vitro-seeded fibrils generated with seeding amplification assay (SAA fibrils) have facilitated αSyn strain research, but the question remains how well they replicate the brain-derived fibrils. The SAA also functions as a highly sensitive and specific diagnostic tool for Parkinson’s di...
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Authors
Contributors
+ Parkkinen, L
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Supervisor
ORCID:
0000-0002-3392-8564
+ Civitelli, L
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Supervisor
ORCID:
0000-0003-2399-1436
+ Chalk, R
Institution:
University of Oxford
Role:
Supervisor
Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- DOI:
Item Description
- Language:
-
English
- Keywords:
- Subjects:
- Deposit date:
-
2024-03-11
Terms of use
- Copyright holder:
- Lee, S
- Copyright date:
- 2023
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