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Trypanosoma brucei PRMT1 is a nucleic acid binding protein with a role in energy metabolism and the starvation stress response

Abstract:

In Trypanosoma brucei and related kinetoplastid parasites, transcription of protein coding genes is largely unregulated. Rather, mRNA binding proteins, which impact processes such as transcript stability and translation efficiency, are the predominant regulators of gene expression. Arginine methylation is a posttranslational modification that preferentially targets RNA binding proteins and is, therefore, likely to have a substantial impact on T. brucei biology. The data presented here demonst...

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Publication status:
Published
Peer review status:
Peer reviewed

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Role:
Author
ORCID:
0000-0002-2587-2150
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Name:
National Institutes of Health
Funder identifier:
http://dx.doi.org/10.13039/100000002
Publisher:
American Society for Microbiology
Journal:
mBio More from this journal
Volume:
9
Issue:
6
Article number:
e02430-18
Publication date:
2018-12-18
Acceptance date:
2018-11-12
DOI:
EISSN:
2150-7511
ISSN:
2150-7511
Pmid:
30563898
Language:
English
Keywords:
Pubs id:
954676
Local pid:
pubs:954676
Deposit date:
2020-08-17

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