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Association of leukocyte DNA methylation changes with dietary folate and alcohol intake in the EPIC Study

Abstract:

Background: There is increasing evidence that folate, an important component of one-carbon metabolism, modulates the epigenome. Alcohol, which can disrupt folate absorption, is also known to affect the epigenome. We investigated the association of dietary folate and alcohol intake on leukocyte DNA methylation levels in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Leukocyte genome-wide DNA methylation profiles on approximately 450,000 CpG sites were acquir...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1186/s13148-019-0637-x

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Publisher:
BioMed Central
Journal:
Clinical Epigenetics More from this journal
Volume:
11
Issue:
2019
Article number:
57
Publication date:
2019-04-02
Acceptance date:
2019-02-20
DOI:
ISSN:
1868-7075
Keywords:
Pubs id:
pubs:976883
UUID:
uuid:0b70dfde-213e-4184-a23f-e934b971cf61
Local pid:
pubs:976883
Source identifiers:
976883
Deposit date:
2019-02-27

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