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Thesis

Macroautophagy, alpha-synuclein and dopamine neurotransmission: implications for Parkinson’s disease

Abstract:

Parkinson’s disease (PD) is an incurable neurological disease characterised by impairment of motor function, death of substantia nigra pars compacta (SNc) dopamine (DA) neurons and accumulation of the protein α-synuclein. Macroautophagy, a major process by which deleterious cellular contents are degraded, is implicated in both sporadic and genetic PD, and macroautophagy inducers are currently in PD clinical trials. However, little is known about the interaction between α-synuclein and macr...

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author

Contributors

Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Supervisor
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Supervisor
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Name:
Rhodes Trust
Funding agency for:
Hunn, BHM
More from this funder
Name:
Guarantors of Brain
Funding agency for:
Hunn, BHM
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:0b3161d2-bca3-49da-af63-a2cc7debaa84
Deposit date:
2018-07-23

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