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Journal article

Developmental role of PHD2 in the pathogenesis of pseudohypoxic pheochromocytoma

Abstract:

Despite a general role for the HIF hydroxylase system in cellular oxygen sensing and tumour hypoxia, cancer-associated mutations of genes in this pathway, including PHD2, PHD1, EPAS1 (encoding HIF 2α) are highly tissue-restricted, being observed in pseudohypoxic pheochromocytoma and paraganglioma (PPGL) but rarely, if ever, in other tumours. In an effort to understand that paradox and gain insights into the pathogenesis of pseudohypoxic PPGL, we constructed mice in which the principal HIF pro...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1530/ERC-21-0211

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Target Discovery Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Target Discovery Institute
Role:
Author
More by this author
Division:
MSD
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Target Discovery Institute
Role:
Author
ORCID:
0000-0001-5937-4849
More by this author
Division:
MSD
Role:
Author
Publisher:
BioScientifica
Journal:
Endocrine-Related Cancer More from this journal
Volume:
28
Issue:
12
Pages:
757–772
Publication date:
2021-10-18
Acceptance date:
2021-09-20
DOI:
EISSN:
1479-6821
ISSN:
1351-0088
Language:
English
Keywords:
Pubs id:
1194297
Local pid:
pubs:1194297
Deposit date:
2021-09-30

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