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Journal article

Effect of a coronary-heart-disease-associated variant of ADAMTS7 on endothelial cell angiogenesis

Abstract:

Background and Aims:
Recent studies have unveiled an association between ADAMTS7 gene variation and coronary artery disease (CAD) caused by atherosclerosis. We investigated if the ADAMTS7 Serine214-to-Proline substitution arising from a CAD-associated variant affected angiogenesis, since neovascularization plays an important role in atherosclerosis.


Methods and Results:
ADAMTS7 knockdown in vascular endothelial cells (ECs) attenua...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Role:
Author
ORCID:
0000-0002-5571-7549
et al.
More by this author
Role:
Author
et al.
Publisher:
Elsevier
Journal:
Atherosclerosis More from this journal
Volume:
296
Pages:
11-17
Publication date:
2020-01-21
Acceptance date:
2020-01-16
DOI:
EISSN:
1879-1484
ISSN:
0021-9150
Language:
English
Keywords:
Pubs id:
1084216
Local pid:
pubs:1084216
Deposit date:
2020-02-02

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