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Proline and water stabilization of a universal two-step folding mechanism for β-turn formation in solution

Abstract:

The atomic scale process by which proteins fold into their functional forms in aqueous solutions is still not well understood. While there is clearly an interplay between the sequence of the protein and the surrounding water solvent that leads to highly specific and reproducible folding in nature, there is still an ongoing debate concerning how water molecules aid in driving the folding process. By using a combination of techniques that provide information at the atomic level—neutron and X-ra...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1021/jacs.8b03643

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More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Oxford college:
St Peters College
Role:
Author
ORCID:
0000-0002-3347-7759
Department of Physics at KCL More from this funder
Publisher:
American Chemical Society Publisher's website
Journal:
Journal of the American Chemical Society Journal website
Volume:
140
Issue:
23
Pages:
7301–7312
Publication date:
2018-05-27
Acceptance date:
2018-05-27
DOI:
EISSN:
1520-5126
ISSN:
0002-7863
Pubs id:
pubs:854460
URN:
uri:0b263275-f2c9-47a7-8612-cdf2b9c45911
UUID:
uuid:0b263275-f2c9-47a7-8612-cdf2b9c45911
Local pid:
pubs:854460
Language:
English

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