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Gonorrhoea treatment failure caused by a Neisseria gonorrhoeae strain with combined ceftriaxone and high-level azithromycin resistance, England, February 2018

Abstract:
We describe a gonorrhoea case with combined highlevel azithromycin resistance and ceftriaxone resistance. In February 2018, a heterosexual male was diagnosed with gonorrhoea in the United Kingdom following sexual intercourse with a locally resident female in Thailand and failed treatment with ceftriaxone plus doxycycline and subsequently spectinomycin. Resistance arose from two mechanisms combining for the first time in a genetic background similar to a commonly circulating strain. Urgent action is essential to prevent further spread.
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.2807/1560-7917.es.2018.23.27.1800323

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Institution:
University of Oxford
Division:
Medical Sciences
Department:
Nuffield Department of Medicine; Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences
Department:
Nuffield Department of Medicine; Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences
Department:
Nuffield Department of Medicine; Experimental Medicine
Role:
Author
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National Institute for Health Research More from this funder
Publisher:
Eurosurveillance Publisher's website
Journal:
Eurosurveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin Journal website
Volume:
23
Issue:
27
Publication date:
2018-07-05
Acceptance date:
2018-07-04
DOI:
EISSN:
1560-7917
ISSN:
1025-496X
Pmid:
29991383
Source identifiers:
869565
Language:
English
Keywords:
Pubs id:
pubs:869565
UUID:
uuid:0b1d8edc-a5ff-4e51-994a-793cab8cbab0
Local pid:
pubs:869565
Deposit date:
2018-07-24

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