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Extracellular matrix complexity in biomarker studies: a novel assay detecting total serum tenascin-C reveals different distribution to isoform-specific assays

Abstract:

Serum biomarkers are the gold standard in non-invasive disease diagnosis and have tremendous potential as prognostic and theranostic tools for patient stratification. Circulating levels of extracellular matrix molecules are gaining traction as an easily accessible means to assess tissue pathology. However, matrix molecules are large, multimodular proteins, subject to a vast array of post-transcriptional and post-translational modifications. These modifications often occur in a tissueand/or di...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.3389/fimmu.2023.1275361

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Author
ORCID:
0000-0002-8813-2977
et al.
Publisher:
Frontiers Media
Journal:
Frontiers in Immunology More from this journal
Volume:
14
Article number:
1275361
Publication date:
2023-11-22
Acceptance date:
2023-10-26
DOI:
EISSN:
1664-3224
Language:
English
Keywords:
Pubs id:
1560738
Local pid:
pubs:1560738
Deposit date:
2023-11-10

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