Journal article
Novel long-chain neurotoxins from Bungarus candidus distinguish the two binding sites in muscle-type nicotinic acetylcholine receptors
- Abstract:
-
αδ-Bungarotoxins, a novel group of long-chain α-neurotoxins, manifest different affinity to two agonist/competitive antagonist binding sites of muscle-type nicotinic acetylcholine receptors, being more active at the interface of α-δ-subunits. Three isoforms (αδ-BgTx-1-3) were identified in Malayan Krait ( Bungarus candidus ) from Thailand by genomic DNA analysis; two of them (αδ-BgTx-1 and 2) were isolated from its venom. The toxins comprise 73 amino acid residues and 5 disulfide bridges, bei...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Bibliographic Details
- Publisher:
- Portland Press Publisher's website
- Journal:
- Biochemical Journal Journal website
- Volume:
- 476
- Issue:
- 8
- Pages:
- 1285-1302
- Publication date:
- 2019-04-03
- Acceptance date:
- 2019-04-03
- DOI:
- EISSN:
-
1470-8728
- ISSN:
-
0264-6021
- Pmid:
-
30944155
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:993243
- UUID:
-
uuid:0afb38f6-8e76-407b-8a2a-8340f86ab2c8
- Local pid:
- pubs:993243
- Source identifiers:
-
993243
- Deposit date:
- 2019-04-21
Terms of use
- Copyright holder:
- Utkin et al.
- Copyright date:
- 2019
- Rights statement:
- © 2019 The Author(s).
- Notes:
- This is the accepted manuscript version of the article. The final version is available online from Portland Press at: https://doi.org/10.1042/BCJ20180909
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