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Novel long-chain neurotoxins from Bungarus candidus distinguish the two binding sites in muscle-type nicotinic acetylcholine receptors

Abstract:

αδ-Bungarotoxins, a novel group of long-chain α-neurotoxins, manifest different affinity to two agonist/competitive antagonist binding sites of muscle-type nicotinic acetylcholine receptors, being more active at the interface of α-δ-subunits. Three isoforms (αδ-BgTx-1-3) were identified in Malayan Krait ( Bungarus candidus ) from Thailand by genomic DNA analysis; two of them (αδ-BgTx-1 and 2) were isolated from its venom. The toxins comprise 73 amino acid residues and 5 disulfide bridges, bei...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1042/bcj20180909

Authors


Publisher:
Portland Press
Journal:
Biochemical Journal More from this journal
Volume:
476
Issue:
8
Pages:
1285-1302
Publication date:
2019-04-03
Acceptance date:
2019-04-03
DOI:
EISSN:
1470-8728
ISSN:
0264-6021
Pmid:
30944155
Language:
English
Keywords:
Pubs id:
pubs:993243
UUID:
uuid:0afb38f6-8e76-407b-8a2a-8340f86ab2c8
Local pid:
pubs:993243
Source identifiers:
993243
Deposit date:
2019-04-21

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