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Comparing co-evolution methods and their application to template-free protein structure prediction.

Abstract:

Co-evolution methods have been used as contact predictors to identify pairs of residues that share spatial proximity. Such contact predictors have been compared in terms of the precision of their predictions, but there is no study that compares their usefulness to model generation.We compared eight different co-evolution methods for a set of ~3,500 proteins and found that metaPSICOV stage 2 produces, on average, the most precise predictions. Precision of all the methods is dependent on SCOP c...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/bioinformatics/btw618

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Department:
Oxford, MPLS, Statistics
Role:
Author
More by this author
Department:
Oxford, MPLS, Statistics
Role:
Author
Publisher:
Oxford University Press Publisher's website
Journal:
Bioinformatics Journal website
Publication date:
2016-09-27
Acceptance date:
2016-09-22
DOI:
EISSN:
1367-4811
ISSN:
1367-4803
Pubs id:
pubs:648272
URN:
uri:0af65cba-5d16-481d-b6ba-85b62ce9c555
UUID:
uuid:0af65cba-5d16-481d-b6ba-85b62ce9c555
Local pid:
pubs:648272
Language:
English
Keywords:

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