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The effect of metformin and GANT61 combinations on the radiosensitivity of prostate cancer cells

Abstract:

The anti-diabetes drug metformin has been shown to have anti-neoplastic effects in several tumor models through its effects on energy metabolism and protein synthesis. Recent studies show that metformin also targets Hedgehog (Hh) signaling, a developmental pathway re-activated in several tumor types, including prostate cancer (PCa). Furthermore, we and others have shown that Hh signaling is an important target for radiosensitization. Here, we evaluated the combination of metformin and the Hh ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.3390/ijms18020399

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Sub department:
CRUK/MRC Ox Inst for Radiation Oncology
Role:
Author
Publisher:
MDPI Publisher's website
Journal:
International Journal of Molecular Sciences Journal website
Volume:
18
Issue:
2
Article number:
399
Publication date:
2017-02-13
Acceptance date:
2017-02-07
DOI:
EISSN:
1422-0067
ISSN:
1661-6596
Source identifiers:
681951
Language:
English
Keywords:
Pubs id:
pubs:681951
UUID:
uuid:0aeeef31-ad08-4193-9a4f-64aaa27b7f28
Local pid:
pubs:681951
Deposit date:
2017-04-20

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