- Abstract:
-
The anti-diabetes drug metformin has been shown to have anti-neoplastic effects in several tumor models through its effects on energy metabolism and protein synthesis. Recent studies show that metformin also targets Hedgehog (Hh) signaling, a developmental pathway re-activated in several tumor types, including prostate cancer (PCa). Furthermore, we and others have shown that Hh signaling is an important target for radiosensitization. Here, we evaluated the combination of metformin and the Hh ...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 2.0mb)
-
- Publisher copy:
- 10.3390/ijms18020399
-
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- Publisher:
- MDPI Publisher's website
- Journal:
- International Journal of Molecular Sciences Journal website
- Volume:
- 18
- Issue:
- 2
- Pages:
- Article: 399
- Publication date:
- 2017-02-13
- Acceptance date:
- 2017-02-07
- DOI:
- EISSN:
-
1422-0067
- ISSN:
-
1661-6596
- Pubs id:
-
pubs:681951
- URN:
-
uri:0aeeef31-ad08-4193-9a4f-64aaa27b7f28
- UUID:
-
uuid:0aeeef31-ad08-4193-9a4f-64aaa27b7f28
- Local pid:
- pubs:681951
- Language:
- English
- Keywords:
- Copyright holder:
- Gonnissen et al.
- Copyright date:
- 2017
- Notes:
-
Copyright © 2017 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access
article distributed under the terms and conditions of the Creative Commons Attribution
(CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Journal article
The effect of metformin and GANT61 combinations on the radiosensitivity of prostate cancer cells
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