Journal article
The effect of metformin and GANT61 combinations on the radiosensitivity of prostate cancer cells
- Abstract:
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The anti-diabetes drug metformin has been shown to have anti-neoplastic effects in several tumor models through its effects on energy metabolism and protein synthesis. Recent studies show that metformin also targets Hedgehog (Hh) signaling, a developmental pathway re-activated in several tumor types, including prostate cancer (PCa). Furthermore, we and others have shown that Hh signaling is an important target for radiosensitization. Here, we evaluated the combination of metformin and the Hh ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 2.0MB)
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- Publisher copy:
- 10.3390/ijms18020399
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Authors
Bibliographic Details
- Publisher:
- MDPI Publisher's website
- Journal:
- International Journal of Molecular Sciences Journal website
- Volume:
- 18
- Issue:
- 2
- Article number:
- 399
- Publication date:
- 2017-02-13
- Acceptance date:
- 2017-02-07
- DOI:
- EISSN:
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1422-0067
- ISSN:
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1661-6596
- Source identifiers:
-
681951
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:681951
- UUID:
-
uuid:0aeeef31-ad08-4193-9a4f-64aaa27b7f28
- Local pid:
- pubs:681951
- Deposit date:
- 2017-04-20
Terms of use
- Copyright holder:
- Gonnissen et al
- Copyright date:
- 2017
- Notes:
-
Copyright © 2017 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access
article distributed under the terms and conditions of the Creative Commons Attribution
(CC BY) license (http://creativecommons.org/licenses/by/4.0/).
- Licence:
- CC Attribution (CC BY)
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