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The effect of metformin and GANT61 combinations on the radiosensitivity of prostate cancer cells

Abstract:

The anti-diabetes drug metformin has been shown to have anti-neoplastic effects in several tumor models through its effects on energy metabolism and protein synthesis. Recent studies show that metformin also targets Hedgehog (Hh) signaling, a developmental pathway re-activated in several tumor types, including prostate cancer (PCa). Furthermore, we and others have shown that Hh signaling is an important target for radiosensitization. Here, we evaluated the combination of metformin and the Hh ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.3390/ijms18020399

Authors


Gonnissen, A More by this author
Isebaert, S More by this author
More by this author
Department:
Oxford, MSD, Oncology
More by this author
Department:
Oxford, MSD, Oncology, CRUK/MRC Ox Inst for Radiation Oncology
Haustermans, K More by this author
Publisher:
MDPI Publisher's website
Journal:
International Journal of Molecular Sciences Journal website
Volume:
18
Issue:
2
Pages:
Article: 399
Publication date:
2017-02-13
Acceptance date:
2017-02-07
DOI:
EISSN:
1422-0067
ISSN:
1661-6596
Pubs id:
pubs:681951
URN:
uri:0aeeef31-ad08-4193-9a4f-64aaa27b7f28
UUID:
uuid:0aeeef31-ad08-4193-9a4f-64aaa27b7f28
Local pid:
pubs:681951

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