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Development of rectal self-emulsifying suspension of a moisture-labile water-soluble drug

Abstract:

Self-emulsifying drug delivery systems, commonly used for oral delivery of poorly soluble compounds, were used to formulate water soluble but moisture labile compounds for rectal application. The objective was to use the oily phase of the system to formulate a liquid, non-aqueous product while obtaining the advantages of self-emulsification, rapid contact with the rectal mucosa and rapid absorption post-administration. Ceftriaxone was used as a model drug and the human bile salt sodium chenod...

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Publication status:
Published
Peer review status:
Peer reviewed

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Authors


Gaubert, A More by this author
Tabaran, L More by this author
Tonelli, G More by this author
Phoeung, T More by this author
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Grand Challenges, Canada More from this funder
Publisher:
Elsevier Publisher's website
Journal:
International Journal of Pharmaceutics Journal website
Volume:
536
Issue:
1
Pages:
283-291
Publication date:
2017-12-02
Acceptance date:
2017-11-28
DOI:
EISSN:
1873-3476
ISSN:
0378-5173
Pubs id:
pubs:908134
URN:
uri:0ab4b19b-5d65-4ab9-915a-00c8ebf8bbfa
UUID:
uuid:0ab4b19b-5d65-4ab9-915a-00c8ebf8bbfa
Local pid:
pubs:908134

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