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A structural model of a P450-ferredoxin complex from orientation-selective double electron-electron resonance spectroscopy

Abstract:

Cytochrome P450 (CYP) monooxygenases catalyze the oxidation of chemically inert carbon-hydrogen bonds in diverse endogenous and exogenous organic compounds by atmospheric oxygen. This C–H bond oxy-functionalization activity has huge potential in biotechnological applications. Class I CYPs receive the two electrons required for oxygen activation from NAD(P)H via a ferredoxin reductase and ferredoxin. The interaction of Class I CYPs with their cognate ferredoxin is specific. In order to reconst...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1021/jacs.7b11056

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Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry
Role:
Author
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Funding agency for:
Bowen, AM
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Publisher:
American Chemical Society Publisher's website
Journal:
Journal of the American Chemical Society Journal website
Volume:
140
Issue:
7
Pages:
2514-2527
Publication date:
2017-12-21
Acceptance date:
2017-12-21
DOI:
EISSN:
1520-5126
ISSN:
0002-7863
Pubs id:
pubs:817409
URN:
uri:0ab0073e-e21b-4755-9e12-b3ecbb261f33
UUID:
uuid:0ab0073e-e21b-4755-9e12-b3ecbb261f33
Local pid:
pubs:817409
Paper number:
7

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