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Binding of Ca2+-independent C2 domains to lipid membranes: a multi-scale molecular dynamics study

Abstract:

C2 domains facilitate protein interactions with lipid bilayers in either a Ca2+-dependent or -independent manner. We used molecular dynamics (MD) simulations to explore six Ca2+-independent C2 domains, from KIBRA, PI3KC2α, RIM2, PTEN, SHIP2, and Smurf2. In coarse-grained MD simulations these C2 domains formed transient interactions with zwitterionic bilayers, compared with longer-lived interactions with anionic bilayers containing phosphatidylinositol bisphosphate (PIP2). Type I C2 domains bo...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.str.2021.05.011

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
Publisher:
Cell Press Publisher's website
Journal:
Structure Journal website
Volume:
29
Issue:
10
Pages:
1200-1213.E2
Publication date:
2021-06-02
Acceptance date:
2021-05-14
DOI:
EISSN:
1878-4186
ISSN:
0969-2126
Language:
English
Keywords:
Pubs id:
1176639
Local pid:
pubs:1176639
Deposit date:
2021-05-17

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