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5T4 oncofoetal glycoprotein: an old target for a novel prostate cancer immunotherapy

Abstract:

The tumour-associated antigen 5T4 is an attractive target for cancer immunotherapy. However to date, reported 5T4-specific cellular immune responses induced by various immunisation platforms have been largely weak or non-existent. In the present study, we have evaluated a heterologous prime boost regime based on the simian adenovirus ChAdOx1 and modified vaccinia virus Ankara (MVA) expressing 5T4 for immunogenicity and tumour protective efficacy in a mouse cancer model. Vaccination-induced im...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.18632/oncotarget.17666

Authors


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Department:
Oxford, MSD, NDM, Jenner Institute
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Department:
Oxford, MSD, NDM, Jenner Institute
Stribbling, S More by this author
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Department:
Oxford, MSD, NDM, Jenner Institute
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Department:
Oxford, MSD, NDM, Jenner Institute
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Grant:
Oxford Biomedical Research Centre, UK (IR)
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Grant:
Senior Investigator’s Award (AVSH)
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Grant:
Seventh Framework Programme under grant agreement No. 602705 ( (FC, EP).
Publisher:
Impact Journals Publisher's website
Journal:
Oncotarget Journal website
Volume:
8
Issue:
29
Pages:
47474-47489
Publication date:
2017-05-07
DOI:
ISSN:
1949-2553
Pubs id:
pubs:698059
URN:
uri:0a97069a-13de-4276-bef3-0adc8e6b4cc3
UUID:
uuid:0a97069a-13de-4276-bef3-0adc8e6b4cc3
Local pid:
pubs:698059

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