- Abstract:
-
The tumour-associated antigen 5T4 is an attractive target for cancer immunotherapy. However to date, reported 5T4-specific cellular immune responses induced by various immunisation platforms have been largely weak or non-existent. In the present study, we have evaluated a heterologous prime boost regime based on the simian adenovirus ChAdOx1 and modified vaccinia virus Ankara (MVA) expressing 5T4 for immunogenicity and tumour protective efficacy in a mouse cancer model. Vaccination-induced im...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 2.4mb)
-
- Publisher copy:
- 10.18632/oncotarget.17666
-
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Some thesis volumes scanned as part of the digitisation scheme funded by Dr Leonard Polonsky are currently unavailable due to sensitive material or uncleared third-party copyright content. We are attempting to contact authors whose theses are affected.
- Grant:
- Oxford Biomedical Research Centre, UK (IR)
- Grant:
- Seventh Framework Programme under grant agreement No. 602705 ( (FC, EP).
- Publisher:
- Impact Journals Publisher's website
- Journal:
- Oncotarget Journal website
- Volume:
- 8
- Issue:
- 29
- Pages:
- 47474-47489
- Publication date:
- 2017-05-07
- DOI:
- ISSN:
-
1949-2553
- Pubs id:
-
pubs:698059
- URN:
-
uri:0a97069a-13de-4276-bef3-0adc8e6b4cc3
- UUID:
-
uuid:0a97069a-13de-4276-bef3-0adc8e6b4cc3
- Local pid:
- pubs:698059
- Language:
- English
- Keywords:
- Copyright holder:
- Cappuccini et al.
- Copyright date:
- 2017
- Notes:
-
Copyright © Cappuccini et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC-BY),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Journal article
5T4 oncofoetal glycoprotein: an old target for a novel prostate cancer immunotherapy
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