Journal article icon

Journal article

5T4 oncofoetal glycoprotein: an old target for a novel prostate cancer immunotherapy

Abstract:

The tumour-associated antigen 5T4 is an attractive target for cancer immunotherapy. However to date, reported 5T4-specific cellular immune responses induced by various immunisation platforms have been largely weak or non-existent. In the present study, we have evaluated a heterologous prime boost regime based on the simian adenovirus ChAdOx1 and modified vaccinia virus Ankara (MVA) expressing 5T4 for immunogenicity and tumour protective efficacy in a mouse cancer model. Vaccination-induced im...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.18632/oncotarget.17666

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
More from this funder
Grant:
Oxford Biomedical Research Centre, UK (IR
More from this funder
Grant:
Senior Investigator’s Award (AVSH
More from this funder
Grant:
Seventh Framework Programme under grant agreement No. 602705 ( (FC, EP)
Publisher:
Impact Journals Publisher's website
Journal:
Oncotarget Journal website
Volume:
8
Issue:
29
Pages:
47474-47489
Publication date:
2017-05-07
Acceptance date:
2017-04-19
DOI:
ISSN:
1949-2553
Source identifiers:
698059
Language:
English
Keywords:
Pubs id:
pubs:698059
UUID:
uuid:0a97069a-13de-4276-bef3-0adc8e6b4cc3
Local pid:
pubs:698059
Deposit date:
2017-07-03

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP