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Boundary behaviours of Leishmania mexicana: a hydrodynamic simulation study

Abstract:

It is well established that the parasites of the genus Leishmania exhibit complex surface interactions with the sandfly vector midgut epithelium, but no prior study has considered the details of their hydrodynamics. Here, the boundary behaviours of motile Leishmania mexicana promastigotes are explored in a computational study using the boundary element method, with a model flagellar beating pattern that has been identified from digital videomicroscopy. In particular a simple flagellar kinemat...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.jtbi.2018.11.016

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Mathematical Institute
Oxford college:
Wadham College
Role:
Author
ORCID:
0000-0003-0853-267X
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Sir William Dunn School of Pathology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Mathematical Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Mathematical Institute
Oxford college:
Brasenose College
Role:
Author
More from this funder
Funding agency for:
Walker, B
Grant:
EP/N509711/1
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Funding agency for:
Wheeler, R
Grant:
Wellcome Trust Investigator Award [104627/Z/14/Z
More from this funder
Funding agency for:
Ishimoto, K
Grant:
OverseasFellowship
MEXTLeadingInitiativeforExcellentYoungResearcher
Publisher:
Elsevier Publisher's website
Journal:
Journal of Theoretical Biology Journal website
Volume:
462
Pages:
311-320
Publication date:
2018-11-20
Acceptance date:
2018-11-15
DOI:
EISSN:
1095-8541
ISSN:
0022-5193
Keywords:
Pubs id:
pubs:857237
UUID:
uuid:0a90949b-1325-4c93-9294-3d4cd7ec5cfb
Local pid:
pubs:857237
Deposit date:
2018-11-16

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