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Randomized controlled trial comparing impact on platelet reactivity of twice‐daily with once‐daily aspirin in people with type 2 diabetes

Abstract:

Aims Reduced aspirin efficacy has been demonstrated in people with Type 2 diabetes. Because increased platelet reactivity and/or turnover are postulated mechanisms, we examined whether higher and/or more frequent aspirin dosing might reduce platelet reactivity more effectively. Methods Participants with Type 2 diabetes (n = 24) but without known cardiovascular disease were randomized in a three‐way crossover design to 2‐week treatment periods with aspirin 100 mg once daily, 200 mg once daily...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1111/dme.12828

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Author
British Heart Foundation More from this funder
Publisher:
Wiley Publisher's website
Journal:
Diabetic Medicine Journal website
Volume:
33
Issue:
2
Pages:
224-230
Publication date:
2016-01-18
Acceptance date:
2015-06-01
DOI:
EISSN:
1464-5491
ISSN:
0742-3071
Pmid:
26043186
Language:
English
Keywords:
Pubs id:
pubs:526321
UUID:
uuid:0a8a41ff-a9e6-4487-ae7a-56c642810e16
Local pid:
pubs:526321
Source identifiers:
526321
Deposit date:
2017-06-06

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