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Genetic and methylation variation in the CYP2B6 gene is related to circulating p,p'-dde levels in a population-based sample

Abstract:

OBJECTIVES: Since the metabolism of the organochlorine pesticide dichlorodiphenyltrichloroethane (DDT) is not fully known in humans, we evaluated if circulating levels of a major breakdown product of DDT, p,p'-DDE, were related to genome-wide genetic and methylation variation in a population-based sample. METHODS: In the population-based Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study (1016 subjects all aged 70), circulating levels of p,p'-DDE were analyzed by hi...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Oxford college:
St John's College
Role:
Author
More from this funder
Name:
Wellcome Trust
Funding agency for:
Morris, A
Grant:
Senior Fellow in Basic Biomedical Science (WT098017
More from this funder
Name:
Svenska Forskningsrådet Formas
Grant:
216-2012-47
Publisher:
Elsevier
Journal:
Environment International More from this journal
Volume:
98
Pages:
212-218
Publication date:
2017-01-01
Acceptance date:
2016-11-08
DOI:
EISSN:
1873-6750
ISSN:
0160-4120
Language:
English
Keywords:
Pubs id:
pubs:659700
UUID:
uuid:0a839c0f-6428-4b5b-bbc5-57b37f279b6c
Local pid:
pubs:659700
Source identifiers:
659700
Deposit date:
2017-01-04

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