Journal article
High OGT activity is essential for MYC-driven proliferation of prostate cancer cells
- Abstract:
-
O-GlcNAc transferase (OGT) is overexpressed in aggressive prostate cancer. OGT modifies intra-cellular proteins via single sugar conjugation (O-GlcNAcylation) to alter their activity. We recently discovered the first fast-acting OGT inhibitor OSMI-2. Here, we probe the stability and function of the chromatin O-GlcNAc and identify transcription factors that coordinate with OGT to promote proliferation of prostate cancer cells.
Methods: Chromatin immunoprecipitation (C... Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Bibliographic Details
- Publisher:
- Ivyspring International Publisher Publisher's website
- Journal:
- Theranostics Journal website
- Volume:
- 9
- Issue:
- 8
- Pages:
- 2183-2197
- Publication date:
- 2019-04-12
- Acceptance date:
- 2019-02-18
- DOI:
- ISSN:
-
1838-7640
Item Description
Terms of use
- Copyright holder:
- Ivyspring International Publisher
- Copyright date:
- 2019
- Notes:
- © Ivyspring International Publisher. This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license
- Licence:
- CC Attribution (CC BY)
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