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Journal article

High OGT activity is essential for MYC-driven proliferation of prostate cancer cells

Abstract:

O-GlcNAc transferase (OGT) is overexpressed in aggressive prostate cancer. OGT modifies intra-cellular proteins via single sugar conjugation (O-GlcNAcylation) to alter their activity. We recently discovered the first fast-acting OGT inhibitor OSMI-2. Here, we probe the stability and function of the chromatin O-GlcNAc and identify transcription factors that coordinate with OGT to promote proliferation of prostate cancer cells.
Methods: Chromatin immunoprecipitation (C... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.7150/thno.30834

Authors


Publisher:
Ivyspring International Publisher
Journal:
Theranostics More from this journal
Volume:
9
Issue:
8
Pages:
2183-2197
Publication date:
2019-04-12
Acceptance date:
2019-02-18
DOI:
ISSN:
1838-7640
Keywords:
Pubs id:
pubs:987544
UUID:
uuid:0a734780-a8e4-4f67-9f09-1000f4c10dbb
Local pid:
pubs:987544
Source identifiers:
987544
Deposit date:
2019-04-04

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