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Journal article

Volume‐localized measurement of oxygen extraction fraction in the brain using MRI

Abstract:

PURPOSE:T2 -relaxation-under-spin-tagging (TRUST) is an MR technique for the non-invasive assessment of whole-brain cerebral oxygen extraction fraction (OEF), through measurement of the venous blood T2 relaxation time in the sagittal sinus. A key limitation of TRUST, however, is the lack of spatial specificity of the measurement. We sought to develop a modified TRUST sequence, selective localized TRUST (SL-TRUST), having sensitivity to venous blood T2 within a targeted brain region, and there...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/mrm.27823

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Oxford college:
Jesus College
Role:
Author
ORCID:
0000-0003-1058-732X
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Nuffield Department of Clinical Neurosciences
Role:
Author
ORCID:
0000-0001-8258-0659
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Nuffield Department of Clinical Neurosciences
Oxford college:
University College
Role:
Author
ORCID:
0000-0001-7912-2251
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Name:
Wellcome Trust
Grant:
203139/Z/16/Z
More from this funder
Name:
Medical Research Council (MRC) Centre for Doctoral Training in Biomedical Imaging
Grant:
EP/L016052/1
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Name:
Oxford NIHR Biomedical Research Centre
More from this funder
Name:
Engineering and Physical Sciences Research Council
Publisher:
Wiley
Journal:
Magnetic Resonance in Medicine More from this journal
Volume:
82
Issue:
4
Pages:
1412-1423
Publication date:
2019-05-27
Acceptance date:
2019-05-01
DOI:
EISSN:
1522-2594
ISSN:
0740-3194
Pmid:
31131930
Language:
English
Keywords:
Pubs id:
pubs:1003448
UUID:
uuid:0a1a420d-6c74-44af-b91a-3c37bea3f53a
Local pid:
pubs:1003448
Source identifiers:
1003448
Deposit date:
2019-05-30

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