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Memo1-mediated tiling of radial glial cells facilitates cerebral cortical development

Abstract:

Polarized, non-overlapping, regularly spaced, tiled organization of radial glial cells (RGCs) serves as a framework to generate and organize cortical neuronal columns, layers, and circuitry. Here, we show that mediator of cell motility 1 (Memo1) is a critical determinant of radial glial tiling during neocortical development. Memo1 deletion or knockdown leads to hyperbranching of RGC basal processes and disrupted RGC tiling, resulting in aberrant radial unit assembly and neuronal layering. Mem...

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Publication status:
Published
Peer review status:
Peer reviewed

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Authors


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Name:
NINDS NIH HHS
Grant:
R01 MH060929
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Name:
NICHD NIH HHS
Grant:
R01 HD098657
Publisher:
Elsevier
Journal:
Neuron More from this journal
Volume:
103
Issue:
5
Pages:
836-852.e5
Publication date:
2019-07-02
Acceptance date:
2019-05-30
DOI:
EISSN:
1097-4199
ISSN:
0896-6273
Pmid:
31277925
Language:
English
Keywords:
Pubs id:
pubs:1028737
UUID:
uuid:09f15c2f-745a-4b63-9d3f-0b367a84e778
Local pid:
pubs:1028737
Source identifiers:
1028737
Deposit date:
2019-12-18

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