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High resolution structural evidence suggests the Sarcoplasmic Reticulum forms microdomains with Acidic Stores (lysosomes) in the heart.

Abstract:

Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) stimulates calcium release from acidic stores such as lysosomes and is a highly potent calcium-mobilising second messenger. NAADP plays an important role in calcium signalling in the heart under basal conditions and following β-adrenergic stress. Nevertheless, the spatial interaction of acidic stores with other parts of the calcium signalling apparatus in cardiac myocytes is unknown. We present evidence that lysosomes are intimately associ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/srep40620

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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
More by this author
Institution:
University of Oxford
Oxford college:
University College
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
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Institution:
University of Oxford
Division:
MPLS
Department:
Computer Science
Role:
Author
More from this funder
Name:
Royal Society
Funding agency for:
Mirams, G
Burton, R
Grant:
101222/Z/13/Z
109371/Z/15/Z
More from this funder
Name:
Wellcome Trust
Funding agency for:
Burton, R
Capel, R
Galione, A
Mirams, G
Grant:
109371/Z/15/Z
109371/Z/15/Z
101222/Z/13/Z
More from this funder
Name:
British Heart Foundation
Funding agency for:
Aston, D
Grant:
RE/08/004
More from this funder
Name:
National Institutes for Health
Grant:
P41GM103431
Publisher:
Nature Publishing Group
Journal:
Scientific Reports More from this journal
Volume:
7
Pages:
40620
Publication date:
2017-01-01
Acceptance date:
2016-12-09
DOI:
ISSN:
2045-2322
Language:
English
Keywords:
Pubs id:
pubs:671734
UUID:
uuid:09db4ffe-3e7c-4a4b-8d3f-cdaaa99b29de
Local pid:
pubs:671734
Deposit date:
2017-01-23

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