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Journal article

Computing threshold antibody levels of protection in vaccine clinical trials: An assessment of methodological bias

Abstract:

In the development of new vaccines, understanding the level of vaccine-induced antibody that is sufficient to protect against disease can simplify and expedite the development and licensing process. If there is an accepted threshold antibody level that is indicative of protection, then smaller trials measuring antibody concentration alone can be conducted to test new vaccines, instead of large efficacy studies powered on clinical outcomes. Commonly, threshold levels of protective antibody are...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0202517

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Primary Care Health Sciences
Oxford college:
All Souls College
Role:
Author
ORCID:
0000-0001-6324-6559
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Paediatrics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Primary Care Health Sciences
Role:
Author
More from this funder
Name:
National Institute for Health Research
Funding agency for:
Voysey, M
Grant:
Doctoral Research Fellowship DRF-2015-08-048
Publisher:
Public Library of Science
Journal:
PLoS ONE More from this journal
Volume:
13
Issue:
9
Article number:
e0202517
Publication date:
2018-09-07
Acceptance date:
2018-08-03
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
Pmid:
30192787
Language:
English
Pubs id:
pubs:918594
UUID:
uuid:09c16e98-5021-478b-809e-7cacc6737db0
Local pid:
pubs:918594
Source identifiers:
918594
Deposit date:
2018-09-12

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