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Chloride dynamics alter the input-output properties of neurons

Abstract:

Fast synaptic inhibition is a critical determinant of neuronal output, with subcellular targeting of synaptic inhibition able to exert different transformations of the neuronal input-output function. At the receptor level, synaptic inhibition is primarily mediated by chloride-permeable Type A GABA receptors. Consequently, dynamics in the neuronal chloride concentration can alter the functional properties of inhibitory synapses. How differences in the spatial targeting of inhibitory synapses i...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pcbi.1007932

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Role:
Author
ORCID:
0000-0002-4809-5059
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Role:
Author
ORCID:
0000-0001-9307-4241
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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
Publisher:
Public Library of Science Publisher's website
Journal:
PLOS Computational Biology Journal website
Volume:
16
Issue:
5
Article number:
e1007932
Publication date:
2020-05-26
Acceptance date:
2020-04-20
DOI:
EISSN:
1553-7358
ISSN:
1553-734X
Language:
English
Keywords:
Pubs id:
1107322
Local pid:
pubs:1107322
Deposit date:
2020-05-28

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