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Molecular epidemiology of P. vivax in Iran: high diversity and complex sub-structure using neutral markers, but no evidence of Y976F mutation at pvmdr1

Abstract:

BACKGROUND: Malaria remains endemic at low levels in the south-eastern provinces of Iran bordering Afghanistan and Pakistan, with the majority of cases attributable to P. vivax. The national guidelines recommend chloroquine (CQ) as blood-stage treatment for uncomplicated P. vivax, but the large influx of imported cases enhances the risk of introducing CQ resistance (CQR). METHODOLOGY AND PRINCIPAL FINDINGS: The genetic diversity at pvmdr1, a putative modulator of CQR, and across nine putative...

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Publication status:
Published
Peer review status:
Peer reviewed

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Name:
Wellcome Trust
Funding agency for:
Price, R
Grant:
091625
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Name:
Hormozgan University of Medical Sciences, Iran
Publisher:
Public Library of Science
Journal:
PLoS One More from this journal
Issue:
11
Publication date:
2016-01-01
Acceptance date:
2016-10-24
Language:
English
Subjects:
Pubs id:
pubs:660322
UUID:
uuid:09aa5027-507a-4977-aeb1-72adb7ff8b82
Local pid:
pubs:660322
Source identifiers:
660322
Deposit date:
2016-11-23

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