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The role of mechanics in the growth and homeostasis of the intestinal crypt

Abstract:

We present a mechanical model of tissue homeostasis that is specialised to the intestinal crypt. Growth and deformation of the crypt, idealised as a line of cells on a substrate, are modelled using morphoelastic rod theory. Alternating between Lagrangian and Eulerian mechanical descriptions enables us precisely to characterise the dynamic nature of tissue homeostasis, whereby the proliferative structure and morphology are static in the Eulerian frame, but there is active migration of Lagrangi...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1007/s10237-020-01402-8

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Mathematical Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Mathematical Institute
Role:
Author
ORCID:
0000-0003-1771-5910
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Mathematical Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Mathematical Institute
Role:
Author
Publisher:
Springer
Journal:
Biomechanics and Modeling in Mechanobiology More from this journal
Volume:
20
Issue:
2021
Pages:
585–608
Publication date:
2020-11-21
Acceptance date:
2020-10-31
DOI:
EISSN:
1617-7940
ISSN:
1617-7940
Language:
English
Keywords:
Pubs id:
1140256
Local pid:
pubs:1140256
Deposit date:
2020-11-02

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