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Lack of LDL receptor enhances amyloid deposition and decreases glial response in an Alzheimer's disease mouse model.

Abstract:

BACKGROUND

Apolipoprotein E (ApoE), a cholesterol carrier associated with atherosclerosis, is a major risk factor for Alzheimer's disease (AD). The low-density lipoprotein receptor (LDLR) regulates ApoE levels in the periphery and in the central nervous system. LDLR has been identified on astrocytes and a number of studies show that it modulates amyloid deposition in AD transgenic mice. However these findings are controversial on whether LDLR deletion is be...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0021880

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Department:
Oxford, MSD, NDM, Target Discovery Institute
Role:
Author

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Role:
Editor
Publisher:
PLoS Publisher's website
Journal:
PloS One Journal website
Volume:
6
Issue:
7
Pages:
e21880
Publication date:
2011-07-06
Acceptance date:
2011-06-11
DOI:
ISSN:
1932-6203
Pubs id:
pubs:614444
URN:
uri:0989a584-1b7d-46a2-8426-2b790a057df3
UUID:
uuid:0989a584-1b7d-46a2-8426-2b790a057df3
Local pid:
pubs:614444

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