Journal article
Loss of complement regulatory proteins on uninfected erythrocytes in vivax and falciparum malaria anemia
- Abstract:
-
Anemia is a major complication of malaria, driven largely by loss of uninfected RBCs during infection. RBC clearance through loss of complement regulatory proteins (CRPs) is a significant contributor to anemia in Plasmodium falciparum infection, but its role in Plasmodium vivax infection is unknown. CRP loss increases RBC susceptibility to macrophage clearance, a process that is also regulated by CD47. We compared CRPs and CD47 expression on infected and uninfected RBCs in adult patients with...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's Version
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- Files:
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(pdf, 832.1KB)
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- Publisher copy:
- 10.1172/jci.insight.124854
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Authors
Funding
+ National Health and Medical Research Council of Australia
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Funding agency for:
Price, RN
+ National Health and Medical Research Council of Australia
More from this funder
Grant:
200909/Z/16/Z
+ Wellcome Trust
More from this funder
Grant:
International Collaborative Research Grant ME928457MES
Bibliographic Details
- Publisher:
- ASCI Publisher's website
- Journal:
- JCI insight Journal website
- Volume:
- 3
- Issue:
- 22
- Pages:
- Article: e124854
- Publication date:
- 2018-11-15
- Acceptance date:
- 2018-10-16
- DOI:
- ISSN:
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2379-3708
- Pubs id:
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pubs:943684
- URN:
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uri:09554e28-ae02-49b3-a836-92026d40a127
- UUID:
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uuid:09554e28-ae02-49b3-a836-92026d40a127
- Local pid:
- pubs:943684
Item Description
- Language:
- English
- Keywords:
Terms of use
- Copyright holder:
- Oyong et al.
- Copyright date:
- 2018
- Notes:
- Copyright © 2018 Oyong et al. This work is licensed under the Creative Commons Attribution 4.0 International License.
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