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Loss of complement regulatory proteins on uninfected erythrocytes in vivax and falciparum malaria anemia

Abstract:

Anemia is a major complication of malaria, driven largely by loss of uninfected RBCs during infection. RBC clearance through loss of complement regulatory proteins (CRPs) is a significant contributor to anemia in Plasmodium falciparum infection, but its role in Plasmodium vivax infection is unknown. CRP loss increases RBC susceptibility to macrophage clearance, a process that is also regulated by CD47. We compared CRPs and CD47 expression on infected and uninfected RBCs in adult patients with...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1172/jci.insight.124854

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Funding agency for:
Price, RN
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Grant:
International Collaborative Research Grant ME928457MES
Publisher:
ASCI Publisher's website
Journal:
JCI insight Journal website
Volume:
3
Issue:
22
Pages:
Article: e124854
Publication date:
2018-11-15
Acceptance date:
2018-10-16
DOI:
ISSN:
2379-3708
Pubs id:
pubs:943684
URN:
uri:09554e28-ae02-49b3-a836-92026d40a127
UUID:
uuid:09554e28-ae02-49b3-a836-92026d40a127
Local pid:
pubs:943684
Language:
English
Keywords:

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