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Cytoglobin is upregulated by tumour hypoxia and silenced by promoter hypermethylation in head and neck cancer

Abstract:

Background:
Cytoglobin (Cygb) was first described in 2002 as an intracellular globin of unknown function. We have previously shown the downregulation of cytoglobin as a key event in a familial cancer syndrome of the upper aerodigestive tract.


Methods:
Cytoglobin expression and promoter methylation were investigated in sporadic head and neck squamous cell carcinoma (HNSCC) using a cross-section of clinical samples. Additionally, th...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/sj.bjc.6605121

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
Publisher:
Springer Nature Publisher's website
Journal:
British Journal of Cancer Journal website
Volume:
101
Issue:
1
Pages:
139-144
Publication date:
2009-06-30
Acceptance date:
2009-05-11
DOI:
EISSN:
1532-1827
ISSN:
0007-0920
Language:
English
Keywords:
Pubs id:
1086355
Local pid:
pubs:1086355
Deposit date:
2020-02-09

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