Journal article
Allele-specific methylation of type 1 diabetes susceptibility genes
- Abstract:
-
The susceptibility to autoimmune diseases is influenced by genes encoding major histocompatibility complex (MHC) proteins. By examining the epigenetic methylation maps of cord blood samples, we found marked differences in the methylation status of CpG sites within the MHC genes (cis-metQTLs) between carriers of the type 1 diabetes risk haplotypes HLA-DRB1*03-DQA1*0501-DQB1*0201 (DR3-DQ2) and HLA-DRB1*04-DQA1*0301-DQB1*0302 (DR4-DQ8). These differences were found in children and adults, and we...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
+ German Federal Ministry of Education and Research
More from this funder
Grant:
HelmholtzZentrumMuenchen,JuvenileDiabetesResearchFoundation(17-2013-525),
iMed–theHelmholtzInitiativeonPersonalizedMedicine
Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Journal of Autoimmunity Journal website
- Volume:
- 89
- Pages:
- 63-74
- Publication date:
- 2017-12-07
- Acceptance date:
- 2017-11-25
- DOI:
- EISSN:
-
1095-9157
- ISSN:
-
0896-8411
- Pmid:
-
29224923
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:810800
- UUID:
-
uuid:08eabf05-8798-44cd-ba6d-e7faff5394bb
- Local pid:
- pubs:810800
- Source identifiers:
-
810800
- Deposit date:
- 2018-02-23
Terms of use
- Copyright holder:
- Kindt et al
- Copyright date:
- 2017
- Notes:
-
Copyright © 2017 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND
license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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