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Journal article

ADAMTS and ADAM metalloproteinases in osteoarthritis - looking beyond the ‘usual suspects’

Abstract:

Introduction

Matrix metalloproteinases and ‘aggrecanase’ ADAMTSs are well established to play key roles in osteoarthritis (OA) through degradation of extracellular matrix type II collagen and aggrecan, and are thus potential targets for development of OA therapies.

Objectives

This paper aims to provide a comprehensive review of the expression and potential roles of other, lesser-known ADAMTSs and related adamalysins (or ADAMs) in cartilage, with a view to identify...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.joca.2017.02.791

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Author
Kennedy Trust for Rheumatology Research More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Osteoarthritis and Cartilage Journal website
Volume:
25
Issue:
7
Pages:
1000–1009
Publication date:
2017-02-01
Acceptance date:
2017-02-07
DOI:
Keywords:
Pubs id:
pubs:679074
UUID:
uuid:08e63c0b-9a6c-43b5-a040-dcbb884f8a1b
Local pid:
pubs:679074
Deposit date:
2017-02-09

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