ADAMTS and ADAM metalloproteinases in osteoarthritis - looking beyond the ‘usual suspects’
Matrix metalloproteinases and ‘aggrecanase’ ADAMTSs are well established to play key roles in osteoarthritis (OA) through degradation of extracellular matrix type II collagen and aggrecan, and are thus potential targets for development of OA therapies.
This paper aims to provide a comprehensive review of the expression and potential roles of other, lesser-known ADAMTSs and related adamalysins (or ADAMs) in cartilage, with a view to identify...Expand abstract
- Publication status:
- Peer review status:
- Peer reviewed
(Version of record, pdf, 1.2MB)
- Publisher copy:
- Copyright holder:
- Troeberg et al
- Copyright date:
- © 2017 Published by Elsevier Ltd on behalf of Osteoarthritis Research Society International. Made available under a Creative Commons license funded by Arthritis Research UK.
- CC Attribution (CC BY)
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