Journal article
Linkage disequilibrium dependent architecture of human complex traits reveals action of negative selection
- Abstract:
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Recent work has hinted at the linkage disequilibrium (LD)-dependent architecture of human complex traits, where SNPs with low levels of LD (LLD) have larger per-SNP heritability. Here we analyzed summary statistics from 56 complex traits (average N = 101,401) by extending stratified LD score regression to continuous annotations. We determined that SNPs with low LLD have significantly larger per-SNP heritability and that roughly half of this effect can be explained by functional an...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted manuscript
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(pdf, 1.4MB)
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(pdf, 1.8MB)
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- Publisher copy:
- 10.1038/ng.3954
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Authors
Funding
+ National Institutes of Health
More from this funder
Grant:
R01 MH101244, R01 MH107649, U01 HG009088
Bibliographic Details
- Publisher:
- Springer Nature Publisher's website
- Journal:
- Nature Genetics Journal website
- Volume:
- 49
- Pages:
- 1421–1427
- Publication date:
- 2017-09-11
- Acceptance date:
- 2017-08-16
- DOI:
- EISSN:
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1546-1718
- ISSN:
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1061-4036
- Pubs id:
-
pubs:727825
- URN:
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uri:08deea57-d220-4b94-99b5-1e68dfca7278
- UUID:
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uuid:08deea57-d220-4b94-99b5-1e68dfca7278
- Local pid:
- pubs:727825
Item Description
Terms of use
- Copyright holder:
- Gazal et al.
- Copyright date:
- 2017
- Notes:
- © 2017 Author(s); published by Macmillan Publishers Limited, part of Springer Nature. All rights reserved. This is the accepted manuscript version of the article. The final version is available online from Springer Nature at: 10.1038/ng.3954
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