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Linkage disequilibrium dependent architecture of human complex traits reveals action of negative selection

Abstract:

Recent work has hinted at the linkage disequilibrium (LD)-dependent architecture of human complex traits, where SNPs with low levels of LD (LLD) have larger per-SNP heritability. Here we analyzed summary statistics from 56 complex traits (average N = 101,401) by extending stratified LD score regression to continuous annotations. We determined that SNPs with low LLD have significantly larger per-SNP heritability and that roughly half of this effect can be explained by functional an...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Files:
Publisher copy:
10.1038/ng.3954

Authors


Finucane, HK More by this author
Furlotee, NA More by this author
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Department:
Corpus Christi College
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Grant:
R01 MH101244, R01 MH107649, U01 HG009088
Publisher:
Springer Nature Publisher's website
Journal:
Nature Genetics Journal website
Volume:
49
Pages:
1421–1427
Publication date:
2017-09-11
Acceptance date:
2017-08-16
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
Pubs id:
pubs:727825
URN:
uri:08deea57-d220-4b94-99b5-1e68dfca7278
UUID:
uuid:08deea57-d220-4b94-99b5-1e68dfca7278
Local pid:
pubs:727825

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