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1α,25‐dihydroxyvitamin D3 in combination with transforming growth factor‐β increases the frequency of Foxp3+ regulatory T cells through preferential expansion and usage of interleukin‐2

Abstract:

A high prevalence of vitamin D insufficiency and deficiency exists worldwide, which is associated with an increased incidence and severity of a range of immune‐mediated diseases. This has resulted in considerable interest in the immunodulatory functions of vitamin D. The active form of vitamin D, 1α,25‐dihydroxyvitamin D3 [1,25(OH)2D3], has been shown to increase the frequency of Foxp3+ CD4+ T regulatory (Treg) cells when present at high concentrations or under strong T‐cell stimulation in cu...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1111/imm.12289

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Author
ORCID:
0000-0001-8339-2094
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Name:
Asthma UK
Grant:
MRC-AsthmaUKCentre
More from this funder
Name:
Medical Research Council
Grant:
G1000758
Publisher:
Wiley
Journal:
Immunology More from this journal
Volume:
143
Issue:
1
Pages:
52-60
Publication date:
2014-07-29
Acceptance date:
2014-03-19
DOI:
EISSN:
1365-2567
ISSN:
0019-2805
Pmid:
24673126
Language:
English
Keywords:
Pubs id:
pubs:482885
UUID:
uuid:08d6e7d9-aa1f-4533-86aa-44b8bc0a717d
Local pid:
pubs:482885
Source identifiers:
482885
Deposit date:
2017-11-28

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