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The role of necrosis, acute hypoxia and chronic hypoxia in 18F-MISO PET image contrast: a computational modelling study

Abstract:

Positron emission tomography (PET) using 18F-fluoromisonidazole (FMISO) is a promising technique for imaging tumour hypoxia, and a potential target for radiotherapy dose-painting. However, the relationship between FMISO uptake and oxygen partial pressure (PO2) is yet to be quantified fully. Tissue oxygenation varies over distances much smaller than clinical PET resolution (<100 µm vs. ~4 mm), and cyclic variations in tumour perfusion have been observed on timescales shorter than typical...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1088/1361-6560/61/24/8596

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Sub department:
CRUK/MRC Ox Inst for Radiation Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Sub department:
CRUK/MRC Ox Inst for Radiation Oncology
Role:
Author
Publisher:
IOP Publishing Publisher's website
Journal:
Physics in Medicine and Biology Journal website
Volume:
61
Issue:
24
Pages:
8596–8624
Publication date:
2016-11-23
Acceptance date:
2016-10-26
DOI:
ISSN:
1361-6560 and 0031-9155
Keywords:
Pubs id:
pubs:656049
UUID:
uuid:08bf45e1-bc15-4642-9f12-26d268cbcd09
Local pid:
pubs:656049
Deposit date:
2016-11-01

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