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From molecular chaperones to membrane motors: through the lens of a mass spectrometrist

Abstract:

Twenty-five years ago, we obtained our first mass spectra of molecular chaperones in complex with protein ligands and entered a new field of gas-phase structural biology. It is perhaps now time to pause and reflect, and to ask how many of our initial structure predictions and models derived from mass spectrometry (MS) datasets were correct. With recent advances in structure determination, many of the most challenging complexes that we studied over the years have become tractable by other stru...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1042/BST20160395

Authors


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Institution:
University of Oxford
Oxford college:
Exeter College
Role:
Author
More from this funder
Name:
Wellcome Trust
Grant:
WT099141
More from this funder
Name:
Medical Research Council
Grant:
98101
More from this funder
Name:
European Research Council
Grant:
ENABLE
Publisher:
Portland Press
Journal:
Biochemical Society Transactions More from this journal
Volume:
45
Issue:
1
Pages:
251-260
Publication date:
2017-02-08
Acceptance date:
2016-12-12
DOI:
EISSN:
1470-8752
ISSN:
0300-5127
Language:
English
Keywords:
Pubs id:
pubs:681693
UUID:
uuid:08ab7173-7aa2-4c7b-9521-f6fd4aa2365f
Local pid:
pubs:681693
Source identifiers:
681693
Deposit date:
2017-03-15

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