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Journal article

Zebrafish earns its stripes for in vivo ASC speck dynamics

Abstract:
Assembly of the ASC speck is critical for signaling by the inflammasome. In this issue, Kuri et al. (2017. J.  Cell Biol. https://doi.org/10.1083/jcb.201703103) use live microscopy to track fluorescently tagged endogenous ASC in the zebrafish, describing the molecular domains driving ASC speck assembly and identifying a key role for macrophages in ASC speck removal in vivo.
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1083/jcb.201708002

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Author
More from this funder
Funding agency for:
Bezbradica, J
Grant:
Senior Fellowship KENN 15 16 06
More from this funder
Grant:
Future Fellowship FT130100361 to K. Schroder
Publisher:
Rockefeller University Press Publisher's website
Journal:
Journal of Cell Biology Journal website
Volume:
216
Issue:
9
Pages:
2615-2618
Publication date:
2017-08-15
Acceptance date:
2017-08-08
DOI:
EISSN:
1540-8140
ISSN:
0021-9525
Pubs id:
pubs:722827
UUID:
uuid:0861530e-007b-4181-85a8-2a6017c05af1
Local pid:
pubs:722827
Source identifiers:
722827
Deposit date:
2017-08-21

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