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Combination of ELISA screening and seroneutralisation tests to expedite Zika virus seroprevalence studies

Abstract:

Here we propose a strategy allowing implementing efficient and practicable large-scale seroepidemiological studies for Zika Virus (ZIKV). It combines screening by a commercial NS1 protein-based Zika IgG ELISA, and confirmation by a cytopathic effect-based virus neutralization test (CPE-based VNT). In post-epidemic samples from Martinique Island blood donors (a population with a dengue seroprevalence above 90%), this strategy allowed reaching specificity and sensitivity values over 98%. The CP...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/s12985-018-1105-5

Authors


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ORCID:
0000-0002-9715-8394
Villarroel, PMS More by this author
Pastorino, B More by this author
Drexler, J-F More by this author
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Publisher:
BioMed Central Publisher's website
Journal:
Virology Journal Journal website
Volume:
15
Issue:
1
Pages:
Article: 192
Publication date:
2018-12-27
Acceptance date:
2018-12-04
DOI:
ISSN:
1743-422X
Pubs id:
pubs:955994
URN:
uri:085b83f1-2ccf-4879-9179-8c29c787085e
UUID:
uuid:085b83f1-2ccf-4879-9179-8c29c787085e
Local pid:
pubs:955994

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