Journal article icon

Journal article

Reducing tumour hypoxia via oral administration of oxygen nanobubbles

Abstract:

Hypoxia has been shown to be a key factor inhibiting the successful treatment of solid tumours. Existing strategies for reducing hypoxia, however, have shown limited efficacy and/or adverse side effects. The aim of this study was to investigate the potential for reducing tumour hypoxia using an orally delivered suspension of surfactant-stabilised oxygen nanobubbles. Experiments were carried out in a mouse xenograft tumour model for human pancreatic cancer (BxPc-3 cells in male SCID mice). A s...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1371/journal.pone.0168088

Authors


More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Engineering Science
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Engineering Science
Role:
Author
More from this funder
Name:
Engineering and Physical Sciences Research Council
Grant:
Impact Acceleration Scheme
Publisher:
Public Library of Science
Journal:
PLoS One More from this journal
Volume:
11
Issue:
12
Article number:
e0168088
Publication date:
2016-01-01
Acceptance date:
2016-11-25
DOI:
ISSN:
1932-6203
Language:
English
Pubs id:
pubs:668973
UUID:
uuid:083d1cb1-b6c7-41a6-a7be-d0fa8b5c08bf
Local pid:
pubs:668973
Source identifiers:
668973
Deposit date:
2017-05-03

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP