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Thesis

The dynamics of hepatic lipid metabolism in humans: understanding their role in fatty liver disease

Abstract:

Non-alcoholic fatty liver disease (NAFLD) has become increasingly prevalent. It is associated with changes in hepatic and whole-body fatty acid (FA) metabolism, with the first stage of the disease, steatosis, characterised by excess triacylglycerol (TAG) storage with a specific (macrovesicular) lipid droplet (LD) pattern; the final step in TAG synthesis is catalysed by diacylglycerol acyltransferase (DGAT). Although the pathogenesis of NAFLD is known to include both genetic and lifestyle f...

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Role:
Author

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Role:
Supervisor
Role:
Supervisor
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:082b4d2d-c022-41a9-a588-8c3747a2d38d
Deposit date:
2019-04-15

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