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Perturbations of native membrane protein structure in alkyl phosphocholine detergents: a critical assessment of NMR and biophysical studies

Abstract:

Membrane proteins perform a host of vital cellular functions. Deciphering the molecular mechanisms whereby they fulfill these functions requires detailed biophysical and structural investigations. Detergents have proven pivotal to extract the protein from its native surroundings. Yet, they provide a milieu that departs significantly from that of the biological membrane, to the extent that the structure, the dynamics, and the interactions of membrane proteins in detergents may considerably var...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1021/acs.chemrev.7b00570

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Oxford college:
Merton College
Role:
Author
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Funding agency for:
Schnell, JR
Grant:
K018590
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Funding agency for:
Pebay-Peyroula, E
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Funding agency for:
Catoire, LJ
Grant:
ANR-13-BSV8-0006-01
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Funding agency for:
Catoire, LJ
Grant:
ANR-13-BSV8-0006-01
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Funding agency for:
Miroux, B
Grant:
ANR-11-LABEX-0011-01
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Publisher:
American Chemical Society Publisher's website
Journal:
Chemical Reviews Journal website
Volume:
118
Issue:
7
Pages:
3559–3607
Publication date:
2018-02-28
Acceptance date:
2018-02-06
DOI:
EISSN:
1520-6890
ISSN:
1520-6890
Source identifiers:
826722
Keywords:
Pubs id:
pubs:826722
UUID:
uuid:0827f129-6c5d-4e05-86c8-d5cdfd665d93
Local pid:
pubs:826722
Deposit date:
2018-02-26

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