Journal article
ATM induces MacroD2 nuclear export upon DNA damage.
- Abstract:
-
ADP-ribosylation is a dynamic post-translation modification that regulates the early phase of various DNA repair pathways by recruiting repair factors to chromatin. ADP-ribosylation levels are defined by the activities of specific transferases and hydrolases. However, except for the transferase PARP1/ARDT1 little is known about regulation of these enzymes. We found that MacroD2, a mono-ADP-ribosylhydrolase, is exported from the nucleus upon DNA damage, and that this nuclear export is induced ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
German Research Foundation
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Ludwig Maximilian University of Munich
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Bibliographic Details
- Publisher:
- Oxford University Press Publisher's website
- Journal:
- Nucleic Acids Research Journal website
- Volume:
- 45
- Issue:
- 1
- Pages:
- 244-254
- Publication date:
- 2016-10-01
- Acceptance date:
- 2016-10-04
- DOI:
- EISSN:
-
1362-4962
- ISSN:
-
0305-1048
- Pmid:
-
28069995
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:694563
- UUID:
-
uuid:08175a05-a634-4dc6-82e3-feb85cae02ff
- Local pid:
- pubs:694563
- Source identifiers:
-
694563
- Deposit date:
- 2018-01-09
Terms of use
- Copyright holder:
- Jankevicius et al
- Copyright date:
- 2016
- Notes:
- © The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
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