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A dynamic model of resource allocation in response to the presence of a synthetic construct

Abstract:

Introducing synthetic constructs into bacteria often carries a burden that leads to reduced fitness and selective pressure for organisms to mutate their constructs and hence to a reduced functional lifetime. Understanding burden requires suitable methods for accurate measurement and quantification. We develop a dynamic growth model from physiologically relevant first-principles that allows parameters relevant to burden to be extracted from standard growth curves. We test several possibilities...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1021/acssynbio.8b00015

Authors


Nyström, A More by this author
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Institution:
University of Oxford
Division:
MPLS Division
Department:
Engineering Science
ORCID:
0000-0002-3565-8967
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Oxford college:
Kellogg College
ORCID:
0000-0003-0075-1480
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Funding agency for:
Angel, A
Publisher:
American Chemical Society Publisher's website
Journal:
ACS Synthetic Biology Journal website
Volume:
7
Issue:
5
Pages:
1201–1210
Publication date:
2018-05-10
Acceptance date:
2018-04-24
DOI:
EISSN:
2161-5063
Pubs id:
pubs:847953
URN:
uri:08126686-7ebc-46b8-8fc2-a091a1c43123
UUID:
uuid:08126686-7ebc-46b8-8fc2-a091a1c43123
Local pid:
pubs:847953
Language:
English
Keywords:

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