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Functional expression of calcium-permeable Canonical Transient Receptor Potential 4-containing channels promotes migration of medulloblastoma cells

Abstract:

Aberrant intracellular Ca(2+) signalling contributes to the formation and progression of a range of distinct pathologies including cancers. Rises in intracellular Ca(2+) concentration occur in response to Ca(2+) influx through plasma membrane channels and Ca(2+) release from intracellular Ca(2+) stores, which can be mobilised in response to activation of cell surface receptors. OGR1 (Ovarian cancer G protein coupled Receptor 1, aka GPR68) is a proton-sensing Gq -coupled receptor that is most ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1113/JP274659

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Department:
Oxford, MSD, Physiology Anatomy and Genetics
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Department:
Oxford, MSD, Physiology Anatomy and Genetics
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Department:
Wadham College
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Department:
Oxford, MSD, Clinical Neurosciences
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Publisher:
John Wiley & Sons Ltd Publisher's website
Journal:
Journal of Physiology Journal website
Volume:
595
Issue:
16
Pages:
5525–5544
Publication date:
2017-07-20
Acceptance date:
2017-06-15
DOI:
EISSN:
1469-7793
ISSN:
0022-3751
Pubs id:
pubs:702265
URN:
uri:080e8462-26f0-4102-9270-5d3262d585ec
UUID:
uuid:080e8462-26f0-4102-9270-5d3262d585ec
Local pid:
pubs:702265
Paper number:
16

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