Journal article
The nature and nurture of cell heterogeneity: accounting for macrophage gene-environment interactions with single-cell RNA-Seq
- Abstract:
-
BACKGROUND: Single-cell RNA-Seq can be a valuable and unbiased tool to dissect cellular heterogeneity, despite the transcriptome's limitations in describing higher functional phenotypes and protein events. Perhaps the most important shortfall with transcriptomic 'snapshots' of cell populations is that they risk being descriptive, only cataloging heterogeneity at one point in time, and without microenvironmental context. Studying the genetic ('nature') and environmental ('nurture') modifiers o...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
John Fell Fund
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Biotechnology and Biological Sciences Research Council
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Bibliographic Details
- Publisher:
- BioMed Central Publisher's website
- Journal:
- BMC Genomics Journal website
- Volume:
- 18
- Issue:
- 1
- Article number:
- 53
- Publication date:
- 2017-01-07
- DOI:
- ISSN:
-
1471-2164
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:669007
- UUID:
-
uuid:0803e59c-95ea-4fdf-a01c-2f45cf6ce6bf
- Local pid:
- pubs:669007
- Deposit date:
- 2017-01-12
Terms of use
- Copyright holder:
- Wills et al
- Copyright date:
- 2017
- Notes:
- Copyright © 2017 the Authors. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
- Licence:
- CC Attribution (CC BY)
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