Journal article
Single genome retrieval of context-dependent variability in mutation rates for human germline.
- Abstract:
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Background
Accurate knowledge of the core components of substitution rates is of vital importance to understand genome evolution and dynamics. By performing a single-genome and direct analysis of 39,894 retrotransposon remnants, we reveal sequence context-dependent germline nucleotide substitution rates for the human genome.
Results
The rates are characterised through rate constants in a time-domain, and are made available through a dedicated program (Trek) and a ...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 2.3MB)
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- Publisher copy:
- 10.1186/s12864-016-3440-5
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Authors
Funding
Herchel Smith Fund
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Bibliographic Details
- Publisher:
- BioMed Central Publisher's website
- Journal:
- BMC Genomics Journal website
- Volume:
- 18
- Issue:
- 1
- Pages:
- 81
- Publication date:
- 2017-01-01
- Acceptance date:
- 2016-12-19
- DOI:
- EISSN:
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1471-2164
- Pmid:
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28086752
- Source identifiers:
-
729655
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:729655
- UUID:
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uuid:07fc39e8-4ae7-49fc-8469-3cf6f8c2188e
- Local pid:
- pubs:729655
- Deposit date:
- 2017-11-10
Terms of use
- Copyright holder:
- Sahakyan and Balasubramanian
- Copyright date:
- 2017
- Notes:
- © The Author(s). 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
- Licence:
- CC Attribution (CC BY)
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