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Journal article

Single genome retrieval of context-dependent variability in mutation rates for human germline.

Abstract:

Background

Accurate knowledge of the core components of substitution rates is of vital importance to understand genome evolution and dynamics. By performing a single-genome and direct analysis of 39,894 retrotransposon remnants, we reveal sequence context-dependent germline nucleotide substitution rates for the human genome.

Results

The rates are characterised through rate constants in a time-domain, and are made available through a dedicated program (Trek) and a ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/s12864-016-3440-5

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM, RDM Clinical Laboratory Sciences
Role:
Author
Herchel Smith Fund More from this funder
Publisher:
BioMed Central Publisher's website
Journal:
BMC Genomics Journal website
Volume:
18
Issue:
1
Pages:
81
Publication date:
2017-01-01
Acceptance date:
2016-12-19
DOI:
EISSN:
1471-2164
Pmid:
28086752
Source identifiers:
729655
Language:
English
Keywords:
Pubs id:
pubs:729655
UUID:
uuid:07fc39e8-4ae7-49fc-8469-3cf6f8c2188e
Local pid:
pubs:729655
Deposit date:
2017-11-10

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