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Bioorthogonal cycloadditions with sub-millisecond intermediates.

Abstract:

Tetrazine- and sydnone-based click chemistries have emerged as important bioconjugation strategies with fast kinetics and N2 or CO2 as the only by-product. Mechanistic studies of these reactions have focused on the initial rate-determining cycloaddition steps. The subsequent N2 or CO2 release from the bicyclic intermediates has been approached mainly through computational studies, which have predicted lifetimes of femtoseconds. In the present study, bioorthogonal cycloadditions involving N2 o...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1002/anie.201710262

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More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemical Biology, Chemistry
Oxford college:
Brasenose College
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemical Biology, Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemical Biology, Chemistry
Role:
Author
European Research Council More from this funder
China Scholarship Council More from this funder
University of Oxford More from this funder
Publisher:
Wiley Publisher's website
Journal:
Angewandte Chemie International Edition Journal website
Publication date:
2018-01-05
Acceptance date:
2017-12-14
DOI:
EISSN:
1521-3773
ISSN:
1433-7851
Pubs id:
pubs:811956
URN:
uri:07f62f35-21fd-404b-ad41-6720d886f27c
UUID:
uuid:07f62f35-21fd-404b-ad41-6720d886f27c
Local pid:
pubs:811956

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