Journal article
Bioorthogonal cycloadditions with sub-millisecond intermediates.
- Abstract:
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Tetrazine- and sydnone-based click chemistries have emerged as important bioconjugation strategies with fast kinetics and N2 or CO2 as the only by-product. Mechanistic studies of these reactions have focused on the initial rate-determining cycloaddition steps. The subsequent N2 or CO2 release from the bicyclic intermediates has been approached mainly through computational studies, which have predicted lifetimes of femtoseconds. In the present study, bioorthogonal cycloadditions involving N2 o...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Accepted manuscript, pdf, 978.4KB)
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- Publisher copy:
- 10.1002/anie.201710262
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Authors
Funding
China Scholarship Council
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European Research Council
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University of Oxford
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Bibliographic Details
- Publisher:
- Wiley Publisher's website
- Journal:
- Angewandte Chemie International Edition Journal website
- Publication date:
- 2018-01-05
- Acceptance date:
- 2017-12-14
- DOI:
- EISSN:
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1521-3773
- ISSN:
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1433-7851
- Pmid:
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29240290
- Source identifiers:
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811956
Item Description
- Language:
- English
- Keywords:
- Pubs id:
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pubs:811956
- UUID:
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uuid:07f62f35-21fd-404b-ad41-6720d886f27c
- Local pid:
- pubs:811956
- Deposit date:
- 2018-01-07
Terms of use
- Copyright holder:
- Wiley‐VCH Verlag GmbH and Co KGaA
- Copyright date:
- 2018
- Notes:
- © 2018 Wiley‐VCH Verlag GmbH and Co. KGaA, Weinheim. This is the accepted manuscript version of the article. The final version is available online from Wiley at: https://doi.org/10.1002/anie.201710262
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