Journal article
Plexin-semaphorin signaling modifies neuromuscular defects in a drosophila model of peripheral neuropathy
- Abstract:
-
Dominant mutations in GARS, encoding the ubiquitous enzyme glycyl-tRNA synthetase (GlyRS), cause peripheral nerve degeneration and Charcot-Marie-Tooth disease type 2D (CMT2D). This genetic disorder exemplifies a recurring paradigm in neurodegeneration, in which mutations in essential genes cause selective degeneration of the nervous system. Recent evidence suggests that the mechanism underlying CMT2D involves extracellular neomorphic binding of mutant GlyRS to neuronally-expressed proteins. C...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Funding
+ Oxford Biomedical Research Centre
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Funding agency for:
Cader, M
Grant:
G0601887
+ French Muscular Dystrophy Association
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Funding agency for:
Sleigh, J
Cader, M
Grant:
103191/A/13/Z
G0601887
+ Medical Research Council
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Funding agency for:
Grice, S
Cader, M
Grant:
G0601887
G0601887
Bibliographic Details
- Publisher:
- Frontiers Media Publisher's website
- Journal:
- Frontiers in Molecular Neuroscience Journal website
- Volume:
- 11
- Issue:
- 55
- Pages:
- 1-11
- Publication date:
- 2018-02-22
- Acceptance date:
- 2018-02-08
- DOI:
- ISSN:
-
1662-5099
Item Description
- Keywords:
- Pubs id:
-
pubs:827807
- UUID:
-
uuid:07e1d521-23f2-4cb4-a2dd-0876ccc6442e
- Local pid:
- pubs:827807
- Source identifiers:
-
827807
- Deposit date:
- 2018-03-05
Terms of use
- Copyright holder:
- © 2018 Grice, Sleigh and Cader
- Copyright date:
- 2018
- Notes:
- This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
- Licence:
- CC Attribution (CC BY)
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