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Metabolic flux analyses to assess the differentiation of adult cardiac progenitors after fatty acid supplementation

Abstract:

Myocardial infarction is the most prevalent of cardiovascular diseases and pharmacological interventions do not lead to restoration of the lost cardiomyocytes. Despite extensive stem cell therapy studies, clinical trials using cardiac progenitor cells have shown moderate results. Furthermore, differentiation of endogenous progenitors to mature cardiomyocytes is rarely reported. A metabolic switch from glucose to fatty acid oxidation occurs during cardiac development and cardiomyocyte maturat...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.scr.2019.101458

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Role:
Author
ORCID:
0000-0002-7208-5598
Publisher:
Elsevier Publisher's website
Journal:
Stem Cell Research Journal website
Volume:
38
Issue:
July 2019
Article number:
101458
Publication date:
2019-05-08
Acceptance date:
2019-05-06
DOI:
EISSN:
1876-7753
ISSN:
1873-5061
Language:
English
Keywords:
Pubs id:
pubs:997053
UUID:
uuid:07cebdb8-2ac0-4760-9f6d-edfdc05df6af
Local pid:
pubs:997053
Source identifiers:
997053
Deposit date:
2019-05-09

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