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Induction of influenza-specific local CD8 T-cells in the respiratory tract after aerosol delivery of vaccine antigen or virus in the Babraham inbred pig

Abstract:

There is increasing evidence that induction of local immune responses is a key component of effective vaccines. For respiratory pathogens, for example tuberculosis and influenza, aerosol delivery is being actively explored as a method to administer vaccine antigens. Current animal models used to study respiratory pathogens suffer from anatomical disparity with humans. The pig is a natural and important host of influenza viruses and is physiologically more comparable to humans than other anima...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.ppat.1007017

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ORCID:
0000-0002-4088-3501
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ORCID:
0000-0002-6332-9108
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
NDM Experimental Medicine
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ORCID:
0000-0002-8655-6741
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Funding agency for:
Tungatt, K
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Funding agency for:
Cole, DK
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Funding agency for:
Cole, DK
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Pathogens Journal website
Volume:
14
Issue:
5
Pages:
Article: e1007017
Publication date:
2018-05-17
Acceptance date:
2018-04-10
DOI:
EISSN:
1553-7374
ISSN:
1553-7366
Pubs id:
pubs:852254
URN:
uri:0790f287-8685-41b7-8152-86ccc4fb9423
UUID:
uuid:0790f287-8685-41b7-8152-86ccc4fb9423
Local pid:
pubs:852254
Language:
English

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