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Induction of influenza-specific local CD8 T-cells in the respiratory tract after aerosol delivery of vaccine antigen or virus in the Babraham inbred pig

Abstract:

There is increasing evidence that induction of local immune responses is a key component of effective vaccines. For respiratory pathogens, for example tuberculosis and influenza, aerosol delivery is being actively explored as a method to administer vaccine antigens. Current animal models used to study respiratory pathogens suffer from anatomical disparity with humans. The pig is a natural and important host of influenza viruses and is physiologically more comparable to humans than other anima...

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Publication status:
Published
Peer review status:
Peer reviewed

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Authors


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Role:
Author
ORCID:
0000-0002-4088-3501
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Role:
Author
ORCID:
0000-0002-6332-9108
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
NDM Experimental Medicine
Department:
Unknown
Role:
Author
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Role:
Author
ORCID:
0000-0002-8655-6741
More from this funder
Name:
Biotechnology and Biological Sciences Research Council
Funding agency for:
Bailey, M
Charleston, B
Sewell, A
Grant:
BB/L001330/1
BB/L001330/1
WT100327MA
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Name:
Diamond Light Source
Funding agency for:
Cole, D
Rizkallah, P
Sewell, A
Grant:
WT095767
WT100327MA
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Name:
Wellcome Trust
Funding agency for:
Cole, D
Sewell, A
Grant:
WT095767
WT100327MA
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Name:
Townsend-Jeantet Charitable Trust
Funding agency for:
Townsend, A
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Name:
Cardiff University
Funding agency for:
Tungatt, K
Publisher:
Public Library of Science
Journal:
PLoS Pathogens More from this journal
Volume:
14
Issue:
5
Article number:
e1007017
Publication date:
2018-05-17
Acceptance date:
2018-04-10
DOI:
EISSN:
1553-7374
ISSN:
1553-7366
Pmid:
29772011
Language:
English
Pubs id:
pubs:852254
UUID:
uuid:0790f287-8685-41b7-8152-86ccc4fb9423
Local pid:
pubs:852254
Source identifiers:
852254
Deposit date:
2018-12-14

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